Which opioid should NOT be administered with Entonox due to potential respiratory depression?

Fentanyl is a potent opioid analgesic that can cause significant respiratory depression, especially when used in conjunction with other respiratory depressants. Entonox, a combination of nitrous oxide and oxygen, is commonly used for pain relief in labor and procedural settings, but it can also have an impact on respiratory dynamics.

When combined with fentanyl, the risk of additive respiratory depression increases, which can be particularly concerning in a clinical setting where respiratory function is critical. This can lead to complications such as hypoventilation or even respiratory arrest, especially in sensitive populations like pregnant women during labor.

Other opioids, while they also carry a risk of respiratory depression, may be considered in specific doses or settings; however, the combination of fentanyl with Entonox is particularly cautioned against due to its high potency and risk profile in this context. Thus, fentanyl should not be administered alongside Entonox to avoid compromising respiratory function.